FADS2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comFADS2 Polyclonal Antibody for Human(Homo sapiens)

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FADS2 (Gene name),

Fatty acid desaturase 2 (Protein name ), FADS2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

FADS2;

Protein name:

Fatty acid desaturase 2;

Alternative:

Delta(6) fatty acid desaturase(D6D;Delta(6) desaturase;Delta-6 desaturase);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

444

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

444:

PLVKSLCAKH | GIEYQEKPLL | RALLDIIRSL | KKSGKLWLDA | YLHK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O95864

STRING:

9606.ENSP00000278840

SMR:

O95864

KEGG:

hsa:9415

Pfam:

PF00173

UniGene:

Hs.502745

MIM:

606149

Uniprot:

O95864

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ELISA Kit for Human Fatty acid desaturase 2

Cat.:

E0400h

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96T

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ELISA Kit for Human Fatty acid desaturase 2

Cat.:

E0400r

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96T

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ELISA Kit for Human Fatty acid desaturase 2

Cat.:

E0400m

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96T

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ELISA Kit for Human Fatty acid desaturase 2

Cat.:

E0400b

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96T

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CLIA Kit for Human Fatty acid desaturase 2

Cat.:

U0400b

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Packing:

96T

CLIA Kit for Human Fatty acid desaturase 2

Cat.:

U0400r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human Fatty acid desaturase 2

Cat.:

U0400h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Fatty acid desaturase 2

Cat.:

U0400m

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Packing:

96T

Polyclonal Antibody for Human Fatty acid desaturase 2

Cat.:

P0400Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Fatty acid desaturase 2

Cat.:

P0400Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Fatty acid desaturase 2

Cat.:

P0400Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Fatty acid desaturase 2

Protein for Human Fatty acid desaturase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase."
Cho H.P. , Nakamura M.T. , Clarke S.D.
J. Biol. Chem.274:471-477(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
2.

"cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family."
Marquardt A. , Stoehr H. , White K. , Weber B.H.
Genomics66:175-183(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
3.

Zhang J.S.S. , Reddel R.R.
Submitted (1998-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Mesothelium.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 277-444 (ISOFORMS 1/2)
tissue: Tongue.
5.

"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Brain.
9.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 134-444 (ISOFORMS 1/2)
tissue: Uterus.
10.

"The E-box like sterol regulatory element mediates the suppression of human Delta-6 desaturase gene by highly unsaturated fatty acids."
Nara T.Y. , He W.S. , Tang C. , Clarke S.D. , Nakamura M.T.
Biochem. Biophys. Res. Commun.296:111-117(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
11.

"Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity."
Ge L. , Gordon J.S. , Hsuan C. , Stenn K. , Prouty S.M.
J. Invest. Dermatol.120:707-714(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

Ge L. , Gordon J.S. , Hsuan C. , Stenn K. , Prouty S.M.
J. Invest. Dermatol.121:434-434(2003)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
13.

"Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element."
Tang C. , Cho H.P. , Nakamura M.T. , Clarke S.D.
J. Lipid Res.44:686-695(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
14.

"Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer."
Lane J. , Mansel R.E. , Jiang W.G.
Int. J. Mol. Med.12:253-257(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
15.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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